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?:abstract
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The clinical spectrum of the perinatal COVID-19 and prospective data on neonatal outcomes remains largely unexplored Most of the existing literature is in the form of case series or single-centre experience In this review, we aim to summarize available literature on the clinical spectrum of COVID-19 in neonates and mothers and suggest a practical approach towards management of clinical scenarios This review explores the clinical characteristics and outcomes of COVID-19 in neonates born to mothers who were detected with the virus during the pregnancy We conducted a comprehensive search of PubMed, Google Scholar and Cochrane Database of Systematic Review between November 2019 and June 2020 and screened articles related to perinatal COVID-19 This review included 786 mothers, among which 64% (504) were delivered by caesarian section There were 3 still births and 107 (14%) were delivered preterm Out of 793 neonates born, 629 neonates (79%) were tested after birth The commonest symptom in neonates was respiratory distress Respiratory support was needed in 60 neonates (7 6%), with 14 babies needing mechanical ventilation (1 8%), 25 needing non-invasive ventilation and 21 needing nasal oxygen Only 35 of the 629 tested neonates (5 5%) were positive for COVID-19 Of the 35 positive neonates, 14 (40%) were symptomatic The COVID-19 seems to have favourable neonatal outcomes Majority of neonates are asymptomatic Respiratory distress is the most common manifestation What is known: •COVID-19 affects all ages •Neonatal disease is usually mild What is new: •Vertical transmission is a possible route of infection in neonates •Breast milk and skin-to-skin contact are safe in COVID-19-infected mothers if performed with appropriate use of precautions such as hand and breast hygiene and masking
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