PropertyValue
?:abstract
  • A global effort is currently undertaken to restrain the COVID-19 pandemic Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease Thus, lymphopenia, T-cell exhaustion, and the increased levels of inflammatory mediators have been described in COVID-19 patients, in particular in severe cases(1) Age represents a key factor in COVID-19 morbidity and mortality(2) Understanding age-associated immune signatures of patients are therefore important to identify preventive and therapeutic strategies In this study, we investigated the immune profile of COVID-19 hospitalized patients identifying a distinctive age-dependent immune signature associated with disease severity Indeed, defined circulating factors - CXCL8, IL-10, IL-15, IL-27, and TNF-α - positively correlate with older age, longer hospitalization, and a more severe form of the disease and may thus represent the leading signature in critical COVID-19 patients
is ?:annotates of
?:creator
?:journal
  • Cell_Death_Dis
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients
?:type
?:who_covidence_id
  • #912894
?:year
  • 2020

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