va4ltg

Property	Value
?:abstract	SIMPLE SUMMARY: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has impacted the world, generating a global health emergency. There is concern about whether cancer patients represent a especially vulnerable to population to this disease, and about the potential influence of different antineoplastic treatments on the risk of contracting the infection and its evolution. With this work, we intend to evaluate the impact of the first wave of the pandemic in our population of cancer patients, analyzing the characteristics and evolution of those patients admitted at our hospital with confirmed diagnosed of SARS-CoV-2 infection, as well as the presence of symptoms and acquired seroprevalence among patients under treatment with different antineoplastic drugs. This knowledge could help to optimize cancer patient management during this period of time, providing information on the risk and outcome of the infection for our patients, and the safety of cancer treatments. ABSTRACT: Background: Studies of patients with cancer affected by coronavirus disease 2019 (COVID-19) are needed to assess the impact of the disease in this sensitive population, and the influence of different cancer treatments on the COVID-19 infection and seroconversion. Material and Methods: We performed a retrospective analysis of all patients hospitalized with RT-PCR positive for COVID-19 in our region to assess the prevalence of cancer patients and describe their characteristics and evolution (Cohort 1). Concurrently, a transversal study was carried out in patients on active systemic cancer treatment for symptomatology and seroprevalence (IgG/IgM by ELISA-method) against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Cohort 2). Results: A total of 215 patients (Cohort 1) were admitted to hospital with a confirmed COVID-19 infection between February 28 and April 30, 2020, and 17 died (7.9%). A medical record of cancer was noted in 43 cases (20%), 6 of them required Intensive care unit ICU attention (14%), and 7 died (16%). There were thirty-six patients (83%) who tested IgG/IgM positive for SARS-CoV-2. Patients on immunosuppressive therapies presented a lower ratio of seroconversion (40% vs. 8%; p = 0.02). In Cohort 2, 166 patients were included in a symptoms-survey and tested for SARS-CoV-2. Any type of potential COVID-19-related symptom was referred up to 67.4% of patients (85.9% vs. 48.2% vs. 73.9%, for patients on chemotherapy, immunotherapy and targeted therapies respectively, p < 0.05). The seroprevalence ratio was 1.8% for the whole cohort with no significant differences by patient or treatment characteristics. Conclusion: Patients with cancer present higher risks for hospital needs for COVID-19 infection. The lack of SARS-CoV-2 seroconversion may be a concern for patients on immunosuppressive therapies. Patients receiving systematic therapies relayed a high rate of potentially COVID-19-related symptoms, particularly those receiving chemotherapy. However, the seroconversion rate remains low and in the range of general population.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/05va4ltg_hasAnnotation_C0006826> <https://research.tib.eu/covid-19/entity/05va4ltg_hasAnnotation_C1457887> <https://research.tib.eu/covid-19/entity/05va4ltg_hasAnnotation_C1706005> <https://research.tib.eu/covid-19/entity/05va4ltg_hasAnnotation_C1825598> <https://research.tib.eu/covid-19/entity/05va4ltg_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Garde-Noguera%2C_Javier%3B_Fern%C3%A1ndez-Murga%2C_M._Leonor%3B_Giner-Bosch%2C_Vicent%3B_Dominguez-M%C3%A1rquez%2C_Victoria%3B_S%C3%A1nchez%2C_Jos%C3%A9_Garc%C3%ADa%3B_Soler-Catalu%C3%B1a%2C_Juan_Jos%C3%A9%3B_L%C3%B3pez_Chuli%C3%A1%2C_Franscica%3B_Honrubia%2C_Beatriz%3B_Piera%2C_Nuria%3B_Llombart-Cussac%2C_Antonio>
?:doi	<https://research.tib.eu/covid-19/entity/10.3390/cancers12123513>
?:doi	10.3390/cancers12123513
?:journal	Cancers_(Basel)
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/77bfe17bad49355e1188af44ca9c8b46dd8b51dc.json
?:pmc_json_files	document_parses/pmc_json/PMC7760084.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7760084>
?:pmid	<https://research.tib.eu/covid-19/entity/33255856.0>
?:pmid	33255856.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/05va4ltg_HAS_C5203670_AFFECTS_C0006826>
?:sha_id	<https://research.tib.eu/covid-19/entity/77bfe17bad49355e1188af44ca9c8b46dd8b51dc>
?:source	Medline; PMC
?:title	Impact of SARS-CoV-2 Infection on Patients with Cancer: Retrospective and Transversal Studies in Spanish Population
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-25

Property

Value

?:abstract

SIMPLE SUMMARY: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has impacted the world, generating a global health emergency. There is concern about whether cancer patients represent a especially vulnerable to population to this disease, and about the potential influence of different antineoplastic treatments on the risk of contracting the infection and its evolution. With this work, we intend to evaluate the impact of the first wave of the pandemic in our population of cancer patients, analyzing the characteristics and evolution of those patients admitted at our hospital with confirmed diagnosed of SARS-CoV-2 infection, as well as the presence of symptoms and acquired seroprevalence among patients under treatment with different antineoplastic drugs. This knowledge could help to optimize cancer patient management during this period of time, providing information on the risk and outcome of the infection for our patients, and the safety of cancer treatments. ABSTRACT: Background: Studies of patients with cancer affected by coronavirus disease 2019 (COVID-19) are needed to assess the impact of the disease in this sensitive population, and the influence of different cancer treatments on the COVID-19 infection and seroconversion. Material and Methods: We performed a retrospective analysis of all patients hospitalized with RT-PCR positive for COVID-19 in our region to assess the prevalence of cancer patients and describe their characteristics and evolution (Cohort 1). Concurrently, a transversal study was carried out in patients on active systemic cancer treatment for symptomatology and seroprevalence (IgG/IgM by ELISA-method) against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Cohort 2). Results: A total of 215 patients (Cohort 1) were admitted to hospital with a confirmed COVID-19 infection between February 28 and April 30, 2020, and 17 died (7.9%). A medical record of cancer was noted in 43 cases (20%), 6 of them required Intensive care unit ICU attention (14%), and 7 died (16%). There were thirty-six patients (83%) who tested IgG/IgM positive for SARS-CoV-2. Patients on immunosuppressive therapies presented a lower ratio of seroconversion (40% vs. 8%; p = 0.02). In Cohort 2, 166 patients were included in a symptoms-survey and tested for SARS-CoV-2. Any type of potential COVID-19-related symptom was referred up to 67.4% of patients (85.9% vs. 48.2% vs. 73.9%, for patients on chemotherapy, immunotherapy and targeted therapies respectively, p < 0.05). The seroprevalence ratio was 1.8% for the whole cohort with no significant differences by patient or treatment characteristics. Conclusion: Patients with cancer present higher risks for hospital needs for COVID-19 infection. The lack of SARS-CoV-2 seroconversion may be a concern for patients on immunosuppressive therapies. Patients receiving systematic therapies relayed a high rate of potentially COVID-19-related symptoms, particularly those receiving chemotherapy. However, the seroconversion rate remains low and in the range of general population.

is ?:annotates of