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COVID-19 is rapidly spreading and there are currently no specific clinical treatments available The absence of an immediate available vaccine against SARS-CoV-2 made it hard for health professionals to tackle the problem Thus, the need of ready to use prescription drugs or herbal remedies is urgent SARS-CoV-2 main protease (Mpro) and Angiotensin Converting Enzyme2 (ACE2) protein structure are made available to facilitate finding solutions to the present problem In this brief research, we compare the efficacy of some natural compounds against COVID-19 Mpro and ACE2 to that of Hydroxy-Chloroquine in silico br Molecular docking investigations were carried out using AutoDock Virtual screening was performed using AutoDock Vina and the best ligand / protein mode was identified based on the binding energy Amino Acids residues of ligands interactions were identified using PyMOL According to present research results, Quercetin, Hispidulin, Cirsimaritin, Sulfasalazine, Artemisin and Curcumin exhibited better potential inhibition than Hydroxy-Chloroquine against COVID-19 main protease active site and ACE2 Our provided docking data of these compounds may helpave a way for further advanced research to the synthesis of novel drug candidate for COVID-19 br
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In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2
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