PropertyValue
?:abstract
  • Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore, we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n = 204), inpatients (cohort B, n = 81), and outpatients later admitted to hospital because of health deterioration (cohort C, n = 23). Iron metabolism parameters were severely altered in patients of cohort B and C compared to cohort A. In multivariate regression analysis including age, gender, CRP and iron-related parameters only serum iron and ferritin were significantly associated with hospitalization. ROC analysis revealed an AUC for serum iron of 0.894 and an iron concentration <6 μmol/l as the best cutoff-point predicting hospitalization with a sensitivity of 94.7% and a specificity of 67.9%. When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Unexpectedly, serum iron levels poorly correlate with hepcidin. We conclude that measurement of serum iron can help predicting the severity of COVID-19. The differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.
is ?:annotates of
?:creator
?:doi
  • 10.1097/hs9.0000000000000492
?:doi
?:journal
  • Hemasphere
?:license
  • cc-by-nc-nd
?:pdf_json_files
  • document_parses/pdf_json/8b58b53080e3d2db09dc6303d398c86c60dac0f1.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7665253.xml.json
?:pmcid
?:pmid
?:pmid
  • 33205000.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Hypoferremia is Associated With Increased Hospitalization and Oxygen Demand in COVID-19 Patients
?:type
?:year
  • 2020-11-10

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