l39bagp

Property	Value
?:abstract	BACKGROUND: We present data on risk factors for severe outcomes among patients with coronavirus disease 2019 (COVID-19) in the southeast United States (U.S.). OBJECTIVE: To determine risk factors associated with hospitalization, intensive care unit (ICU) admission, and mortality among patients with confirmed COVID-19. DESIGN: A retrospective cohort study. SETTING: Fulton County in Atlanta Metropolitan Area, Georgia, U.S. PATIENTS: Community-based individuals of all ages that tested positive for SARS-CoV-2. MEASUREMENTS: Demographic characteristics, comorbid conditions, hospitalization, ICU admission, death (all-cause mortality), and severe COVID-19 disease, defined as a composite measure of hospitalization and death. RESULTS: Between March 2 and May 31, 2020, we included 4322 individuals with various COVID-19 outcomes. In a multivariable logistic regression random-effects model, patients in age groups ≥45 years compared to those <25 years were associated with severe COVID-19. Males compared to females (adjusted odds ratio [aOR] 1.4, 95% confidence interval [CI]: 1.1–1.6), non-Hispanic blacks (aOR 1.9, 95%CI: 1.5–2.4) and Hispanics (aOR 1.7, 95%CI: 1.2–2.5) compared to non-Hispanic whites were associated with increased odds of severe COVID-19. Those with chronic renal disease (aOR 3.6, 95%CI: 2.2–5.8), neurologic disease (aOR 2.8, 95%CI: 1.8–4.3), diabetes (aOR 2.0, 95%CI: 1.5–2.7), chronic lung disease (aOR 1.7, 95%CI: 1.2–2.3), and “other chronic diseases” (aOR 1.8, 95%CI: 1.3–2.6) compared to those without these conditions were associated with increased odds of having severe COVID-19. CONCLUSIONS: Multiple risk factors for hospitalization, ICU admission, and death were observed in this cohort from an urban setting in the southeast U.S. Improved screening and early, intensive treatment for persons with identified risk factors is urgently needed to reduce COVID-19 related morbidity and mortality.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/0l39bagp_hasAnnotation_C1415068> <https://research.tib.eu/covid-19/entity/0l39bagp_hasAnnotation_C3541329> <https://research.tib.eu/covid-19/entity/0l39bagp_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Chishinga%2C_Nathaniel%3B_Gandhi%2C_Neel_R.%3B_Onwubiko%2C_Udodirim_N.%3B_Telford%2C_Carson%3B_Prieto%2C_Juliana%3B_Smith%2C_Sasha%3B_Chamberlain%2C_Allison_T.%3B_Khan%2C_Shamimul%3B_Williams%2C_Steve%3B_Khan%2C_Fazle%3B_Shah%2C_Sarita>
?:doi	10.1101/2020.12.15.20248214
?:doi	<https://research.tib.eu/covid-19/entity/10.1101/2020.12.15.20248214>
?:journal	medRxiv
?:license	cc-by-nd
?:pdf_json_files	document_parses/pdf_json/236ab064620a6676d03f672b25ed1295dd2fd5f0.json; document_parses/pdf_json/4245c82d8f38ea80304598f2fa0680db7105a71d.json
?:pmc_json_files	document_parses/pmc_json/PMC7755152.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7755152>
?:pmid	<https://research.tib.eu/covid-19/entity/33354690.0>
?:pmid	33354690.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/0l39bagp_HAS_C1415068_ASSOCIATED_WITH_C0008679>
?:sha_id	<https://research.tib.eu/covid-19/entity/236ab064620a6676d03f672b25ed1295dd2fd5f0%3B%204245c82d8f38ea80304598f2fa0680db7105a71d>
?:source	MedRxiv; Medline; PMC; WHO
?:title	Characteristics and Risk Factors for Hospitalization and Mortality among Persons with COVID-19 in Atlanta Metropolitan Area
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-16

Property

Value

?:abstract

BACKGROUND: We present data on risk factors for severe outcomes among patients with coronavirus disease 2019 (COVID-19) in the southeast United States (U.S.). OBJECTIVE: To determine risk factors associated with hospitalization, intensive care unit (ICU) admission, and mortality among patients with confirmed COVID-19. DESIGN: A retrospective cohort study. SETTING: Fulton County in Atlanta Metropolitan Area, Georgia, U.S. PATIENTS: Community-based individuals of all ages that tested positive for SARS-CoV-2. MEASUREMENTS: Demographic characteristics, comorbid conditions, hospitalization, ICU admission, death (all-cause mortality), and severe COVID-19 disease, defined as a composite measure of hospitalization and death. RESULTS: Between March 2 and May 31, 2020, we included 4322 individuals with various COVID-19 outcomes. In a multivariable logistic regression random-effects model, patients in age groups ≥45 years compared to those <25 years were associated with severe COVID-19. Males compared to females (adjusted odds ratio [aOR] 1.4, 95% confidence interval [CI]: 1.1–1.6), non-Hispanic blacks (aOR 1.9, 95%CI: 1.5–2.4) and Hispanics (aOR 1.7, 95%CI: 1.2–2.5) compared to non-Hispanic whites were associated with increased odds of severe COVID-19. Those with chronic renal disease (aOR 3.6, 95%CI: 2.2–5.8), neurologic disease (aOR 2.8, 95%CI: 1.8–4.3), diabetes (aOR 2.0, 95%CI: 1.5–2.7), chronic lung disease (aOR 1.7, 95%CI: 1.2–2.3), and “other chronic diseases” (aOR 1.8, 95%CI: 1.3–2.6) compared to those without these conditions were associated with increased odds of having severe COVID-19. CONCLUSIONS: Multiple risk factors for hospitalization, ICU admission, and death were observed in this cohort from an urban setting in the southeast U.S. Improved screening and early, intensive treatment for persons with identified risk factors is urgently needed to reduce COVID-19 related morbidity and mortality.

is ?:annotates of