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The coronavirus disease-2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) has exacted an enormous toll on healthcare systems worldwide The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients The sparsity of viable treatment options for this viral infection and the sequelae of pulmonary complications have fueled the quest for new therapeutic considerations One such option, the long-forgotten idea of using low dose radiation therapy (LDRT), has recently found renewed interest in many academic centers We outline the scientific and logistical rationale for consideration of this option and the mechanistic underpinnings of any potential therapeutic value, particularly as viewed from an immunological perspective We also discuss the preliminary and/or published results of prospective trials examining LDRT for COVID-19
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Low-dose radiation therapy for COVID-19 – promises and pitfalls
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