PropertyValue
?:abstract
  • Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10(−3) substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
?:creator
?:doi
?:doi
  • 10.3201/eid2701.201543
?:journal
  • Emerg_Infect_Dis
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/ed1a9f9348e5d1c0bbd91d829e4c421784d90d2b.json; document_parses/pdf_json/a8f038acce9e776d838ae5f27025a1bbceb1e3bb.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7774584.xml.json
?:pmcid
?:pmid
?:pmid
  • 33350913.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China
?:type
?:year
  • 2021-01-15

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