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The evolutionary change of SARS-CoV-2 is of the outmost concern. With a more stable phenotype, mutation D614G has become dominant. Its structural impact prompts the development of an antibody that destabilizes the virus quaternary structure where it is most vulnerable. Vaccine-related antigenic regions are different from the proposed epitope, hence avoiding therapeutic redundancy.
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ACS_pharmacology_&_translational_science
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?:title
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Therapeutically Targeted Destabilization of the Quaternary Structure of the Spike Protein in the Dominant G614 Strain of SARS-CoV-2.
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