PropertyValue
?:abstract
  • The new coronavirus type SARS-Cov 2 (severe acute respiratory syndrome), which appeared in autumn 2019 in China, became a global pandemic in a few months In this work, we looked for the potential antSARS-Cov 2 of the compounds isolated from three Djiboutian medicinal plants namely Acacia seyal, Cymbopogon commutatus, and Indigofera caerulea For this we carried out a docking with nine biomolecules, β-Sitosterol , Quercetin, Catechin, Lupeol, Rutin, Kaempferol, Gallic acid, Piperitone and Limonene on three target sites which are SARS-CoV-2 main protease (Mp), SARS-CoV-2 receptor binding domain (RBD) and human furin protease These targets are chosen because of their role in the process of penetration of the virus into human cells and its multiplication The phenolic compounds have a very good afinity on these three target sites with binding energies of uto -9 098 kcal/mol for rutin on SARS-CoV-2 Mp, much better than the two reference drugs hydroxychloroquine (-5 816 kcal / mol) and remdesivir (-7 194 kcal/mol) These natural compounds do not present toxicities and can be used pending In vitro and In vivo evaluations
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Natural Compounds from Djiboutian Medicinal Plants as Inhibitors of COVID-19 by in Silico Investigations
?:type
?:who_covidence_id
  • #50
?:year
  • 2020

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