PropertyValue
?:abstract
  • SUMMARY Hydroxychloroquine is being investigated for a potential prophylactic effect in SARS-CoV-2 infection, but its mechanism of action is poorly understood Circulating leukocytes from the blood of COVID-19 patients show increased responses to Toll-Like Receptor ligands, suggestive of innate immune reprogramming By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Candida the trained innate immunity can be modeled in vitro In this model hydroxychloroquine inhibits the responsiveness of these innate immune cells to virus-like stimuli and interferons This is associated with suppression of histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation of inflammation-related genes, changes in the cellular lipidome, and decreased expression of interferon-stimulated genes Our findings indicate that hydroxychloroquine inhibits trained immunity in vitro, which may not be beneficial for the antiviral innate immune response to SARS-CoV-2 infection in patients
is ?:annotates of
?:creator
?:journal
  • Cell_Reports_Medicine
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Hydroxychloroquine inhibits the trained innate immune response to interferons
?:type
?:who_covidence_id
  • #917453
?:year
  • 2020

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