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?:abstract
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COVID-19 control efforts have been hampered by transmission from pre-symptomatic individuals infected with SARS-CoV2. Prolonged asymptomatic respiratory viral shedding in children has been described and may be another important reservoir for ongoing transmission. The primary diagnostic approach to identify SARS-CoV2 infection relies on qPCR of specific viral sequences from respiratory samples, which is expensive, uncomfortable, relatively slow, and susceptible to false-negative results. A rapid non-invasive method to detect mild or asymptomatic infection would have a major impact on public health campaigns to control COVID-19. We hypothesize that candidate biomarkers characterize the exhaled breath of children with SARS-CoV2 infection. To test this hypothesis, we enrolled SARS-CoV-2-infected and -uninfected children admitted to a major pediatric academic medical center and analyzed their breath volatile composition. Targeted volatiles analysis revealed that six volatile organic compounds increased significantly in SARS-CoV-2-infected children. Three aldehydes (octanal, nonanal, and heptanal) drew special attention as candidate biomarkers, because viral infections have previously been shown to induce aldehyde production. Together, these biomarkers demonstrated 100% sensitivity and 66.6% specificity. Our work provides a solid framework upon which to build a future “breathalyzer” test for SARS-CoV-2 infection in children.
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?:doi
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10.1101/2020.12.04.20230755
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document_parses/pdf_json/b1a46b69a6643d9e017b8f9380ab0819458b234a.json; document_parses/pdf_json/a99b6ef2a44f3ec9185faf4283b93ec309d447d0.json; document_parses/pdf_json/44f6d056f3d75092efd5053a1da0d121ca2be0a3.json
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document_parses/pmc_json/PMC7743102.xml.json
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MedRxiv; Medline; PMC; WHO
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?:title
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Breath biomarkers of pediatric SARS-CoV-2 infection: a pilot study
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