PropertyValue
?:abstract
  • The aim of the present research work is to screen and assess the selected plant alkaloids as potential COVID-19 main protease enzyme (Mpro) inhibitors, using molecular docking study We have selected several plant alkaloids which are having antiviral activity which includes berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformaline, perivine and vincaleucoblastine used as ligands to study the interaction with selected target of COVID-2019 Nelfinavir and lopinavir were used as standard antiviral agents for comparison COVID-19 Mpro was docked with selected compounds using PyRx 0 8 and docking was analysed by PyRx 0 8 and Biovia Discovery Studio 2019 The binding energies obtained from the docking of 6LU7 with lopinavir, nelfinavir, berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine were-8, -8 3, -6 8, -7, - 6 5, -7 8, -7, -8 1, -7 3, -7 2, -7 3 and -7 3 kcal/mol, respectively From the binding energy calculations we can conclude that nelfinavir and lopinavir may represent potential treatment options and berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine found to possess the best inhibitors of COVID-19 Mpro Copyright © Journal of Global Trends in Pharmaceutical Sciences
is ?:annotates of
?:creator
?:journal
  • Journal_of_Global_Trends_in_Pharmaceutical_Sciences
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Screening and assessment of selected alkaloids as potential inhibitors of COVID-19 protease enzyme
?:type
?:who_covidence_id
  • #660832
?:year
  • 2020

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