PropertyValue
?:abstract
  • Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt(lum)/Ct(cyt)). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and host components and contribute to establish the basis to tackle the pathogenesis of SARS-CoV-2.
?:creator
?:doi
  • 10.1098/rsob.200209
?:doi
?:journal
  • Open_Biol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/f763e7edf2ae2a5596b0fdc6889e6450c29fa0d2.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7536074.xml.json
?:pmcid
?:pmid
?:pmid
  • 32898469.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • SARS-CoV-2 envelope protein topology in eukaryotic membranes
?:type
?:year
  • 2020-09-09

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