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[ ]perhaps it is self-evident that harmonisation of clinical investigation during outbreaks is desirable In 2016, the ISARIC/WHO CCP was implemented in Brazil in response to the emergence of Zika virus and chikungunya virus in Latin America, facilitating studies of viral shedding and serology 2 The CCP was also used for the establishment of cohort studies of critically ill patients with Middle East respiratory syndrome 3 At present, the Uganda Virus Research Institute (Entebbe, Uganda) is using the protocol to study severe acute febrile illness and severe influenza 4 The value of this approach is becoming apparent in the age of COVID-19 The original reports on clinical findings in COVID-19 used harmonised data collection 5,6 46 countries have registered to record clinical data using the ISARIC/WHO CCP Case Report Form and investigators in many countries are planning to use the CCP biological sampling protocol to coordinate studies of transmission, prognostication, pathogenesis, and diagnostics (appendix)
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