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?:abstract	Analysis of 772 complete SARS-CoV-2 genomes from early in the Boston area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, while other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed significantly in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help understand the link between individual clusters and wider community spread. Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases The data revealed two superspreading events One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread
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?:journal	Science Science_(Wash.)
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	WHO
?:title	Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1066802 #971301
?:year	2020 2021

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Value

?:abstract

Analysis of 772 complete SARS-CoV-2 genomes from early in the Boston area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, while other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed significantly in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help understand the link between individual clusters and wider community spread.
Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases The data revealed two superspreading events One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread

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