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?:abstract
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BACKGROUND: Acute myocardial injury and heart failure characterized by elevated cardiac troponin and decreased heart pump function are significant clinical features and prognostic factors of coronavirus disease-19 (COVID-19) Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19 METHODS: Ninety-eight laboratory-confirmed patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan, China, were enrolled in this retrospective study Regression models were used to investigate the association between TG/HDL-C ratio with myocardial injury, heart failure, severity, and mortality in COVID-19 RESULTS: Among the 98 patients, the mean age was 63 9±1 4 years, and male sex (58, 59%) was predominant Forty-six patients (47%) were admitted to the intensive care unit (ICU), 32 (33%) and 46 (47%) patients suffered from myocardial injury and heart failure, respectively, and 36 (37%) patients died The TG/HDL-C ratio was increased in patients with myocardial injury, heart failure, severe illness, and fatal outcome (P<0 05 for each) Baseline TG/HDL-C ratio significantly correlated with log transformed levels of plasma high-sensitivity cardiac troponin I (r=0 251, P=0 018), N-terminal brain natriuretic propeptide (r=0 274, P=0 008), glycated hemoglobin (r=0 239, P=0 038), and interleukin-6 (r=0 218, P=0 042) Multivariate logistic regression analysis showed that an increased TG/HDL-C ratio was independently associated with the risk of myocardial injury [odds ratio (OR)=2 73;P=0 013], heart failure (OR=2 64;P=0 019), disease severity (OR=3 01;P=0 032), and fatal outcome (OR=2 97;P=0 014) CONCLUSION: Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome
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