PropertyValue
?:abstract
  • OBJECTIVE: ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic SARS-CoV-2 This mini-review explores the potential of targeting ACE2 in blocking viral penetrance MATERIALS AND METHODS: PubMed search was conducted using the terms: \'coronaviridae\', \'peptidyl-dipeptidase A\', \'ACE2\', \'SARS\', and \'SARS-CoV-2\' References of relevant articles were further screened by the author RESULTS: Four main methods of blocking ACE2-mediated viral penetrance were identified: receptor blockage, receptor decoying, receptor shedding, and co-receptor inhibition CONCLUSIONS: Drugs that inhibit viral binding to ACE2 present a strong choice for the current, and if necessary, future outbreaks Further research is needed to establish the clinical and pharmacological aspects of the identified candidate molecules
is ?:annotates of
?:creator
?:journal
  • Eur_Rev_Med_Pharmacol_Sci
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • The therapeutic potential of targeting ACE2 in COVID-19
?:type
?:who_covidence_id
  • #814894
?:year
  • 2020

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