qllwvp1 | Knowledge4COVID-19

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?:abstract	The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2 We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2 Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro It might be a feasible tool for the prevention and control of ongoing COVID-19 The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C0063355> <https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C0596988> <https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C1175743> <https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C1422064> <https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C4556170> <https://research.tib.eu/covid-19/entity/1qllwvp1_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Wei%2C_S.%3B_Duan%2C_S.%3B_Liu%2C_X.%3B_Wang%2C_H.%3B_Ding%2C_S.%3B_Chen%2C_Y.%3B_Xie%2C_J.%3B_Tian%2C_J.%3B_Yu%2C_N.%3B_Ge%2C_P.%3B_Zhang%2C_X.%3B_Chen%2C_X.%3B_Li%2C_Y.%3B_Meng%2C_Q.> <https://research.tib.eu/covid-19/entity/Wei%2C_Shuangshi%3B_Duan%2C_Shengbao%3B_Liu%2C_Xiaomei%3B_Wang%2C_Hongmei%3B_Ding%2C_Shaohua%3B_Chen%2C_Yezhou%3B_Xie%2C_Jinsong%3B_Tian%2C_Jingjing%3B_Yu%2C_Nong%3B_Ge%2C_Pingju%3B_Zhang%2C_Xinglin%3B_Chen%2C_Xiaohong%3B_Li%2C_Yong%3B_Meng%2C_Qinglin>
?:journal	Int_Immunopharmacol International_Immunopharmacology
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/1qllwvp1_HAS_C3658243_INTERACTS_WITH_C1422064> <https://research.tib.eu/covid-19/entity/1qllwvp1_HAS_C5391442_INTERACTS_WITH_C1422064>
?:source	WHO
?:title	Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1065214 #899022
?:year	2020 2021

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