PropertyValue
?:abstract
  • The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV and SARS-CoV-2. Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, spreads rapidly and since the discovery of the first COVID-19 infection in December 2019, has caused 1.2 million deaths worldwide and 226,777 deaths in the United States alone. The high amino acid similarity between SARS-CoV-1 and SARS-CoV-2 viral proteins supports testing therapeutic molecules that were designed to treat SARS infections during the 2003 epidemic. In this review, we provide information on possible COVID-19 treatment strategies that act via inhibition of the two essential proteins of the virus, 3C-like protease (3CLpro ) or papain-like protease (PLpro ). This article is protected by copyright. All rights reserved.
?:creator
?:doi
?:doi
  • 10.1002/jmv.26814
?:journal
  • Journal_of_medical_virology
?:license
  • unk
?:pmid
?:pmid
  • 33475167
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • Targeting SARS-CoV-2 Viral Proteases as a Therapeutic Strategy to Treat COVID-19.
?:type
?:year
  • 2021-01-21

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