yv0koil

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?:abstract	BACKGROUND: Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of the clinical management of pandemic. To improve the outcome, identification of patients at the highest risk seems mandatory. OBJECTIVES: Aim of this study is to identify comorbidities and clinical conditions upon admission associated with in-hospital mortality in several COVID Centers in Campania Region (Italy). METHODS: COVOCA is a multicentre retrospective observational cohort study, which involved 18 COVID Centers throughout Campania Region, Italy. Data were collected from patients who completed their hospitalization between March-June 2020. The endpoint was in-hospital mortality, assessed either from data at discharge or death certificate, whilst all exposure variables were collected at hospital admission. RESULTS: Among 618 COVID-19 hospitalized patients included in the study, 143 in-hospital mortality events were recorded, with a cumulative incidence of about 23%. At multivariable logistic analysis, male sex (OR 2.63, 95%CI 1.42–4.90; p = 0.001), Chronic Liver Disease (OR 5.88, 95%CI 2.39–14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21–5.68; p = 0.015) disclosed an independent association with a poor prognosis, Glasgow Coma Scale (GCS) and Respiratory Severity Scale allowed to identify at higher mortality risk. Sensitivity analysis further enhanced these findings. CONCLUSION: Mortality of patients hospitalized for COVID-19 appears strongly affected by both clinical conditions on admission and comorbidities. Originally, we observed a very poor outcome in subjects with a chronic liver disease, alongside with an increase of hepatic damage.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/1yv0koil_hasAnnotation_C0006826> <https://research.tib.eu/covid-19/entity/1yv0koil_hasAnnotation_C0020517> <https://research.tib.eu/covid-19/entity/1yv0koil_hasAnnotation_C0151763> <https://research.tib.eu/covid-19/entity/1yv0koil_hasAnnotation_C1825598>
?:creator	<https://research.tib.eu/covid-19/entity/Galiero%2C_Raffaele%3B_Pafundi%2C_Pia_Clara%3B_Simeon%2C_Vittorio%3B_Rinaldi%2C_Luca%3B_Perrella%2C_Alessandro%3B_Vetrano%2C_Erica%3B_Caturano%2C_Alfredo%3B_Alfano%2C_Maria%3B_Beccia%2C_Domenico%3B_Nevola%2C_Riccardo%3B_Marfella%2C_Raffaele%3B_Sardu%2C_Celestino%3B_Coppola%2C_Carmine%3B_Scarano%2C_Ferdinando%3B_Maggi%2C_Paolo%3B_De_Lucia_Sposito%2C_Pellegrino%3B_Vocciante%2C_Laura%3B_Rescigno%2C_Carolina%3B_Sbreglia%2C_Costanza%3B_Fraganza%2C_Fiorentino%3B_Parrella%2C_Roberto%3B_Romano%2C_Annamaria%3B_Calabria%2C_Giosuele%3B_Polverino%2C_Benedetto%3B_Pagano%2C_Antonio%3B_Bologna%2C_Carolina%3B_Amitrano%2C_Maria%3B_Esposito%2C_Vincenzo%3B_Coppola%2C_Nicola%3B_Maturo%2C_Nicola%3B_Adinolfi%2C_Luigi_Elio%3B_Chiodini%2C_Paolo%3B_Sasso%2C_Ferdinando_Carlo>
?:doi	<https://research.tib.eu/covid-19/entity/10.1371/journal.pone.0243700>
?:doi	10.1371/journal.pone.0243700
?:journal	PLoS_One
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/7253120227b39327c83031b87609cafcf1411d86.json
?:pmc_json_files	document_parses/pmc_json/PMC7728173.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7728173>
?:pmid	<https://research.tib.eu/covid-19/entity/33301529.0>
?:pmid	33301529.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/7253120227b39327c83031b87609cafcf1411d86>
?:source	Medline; PMC
?:title	Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-10

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Value

?:abstract

BACKGROUND: Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of the clinical management of pandemic. To improve the outcome, identification of patients at the highest risk seems mandatory. OBJECTIVES: Aim of this study is to identify comorbidities and clinical conditions upon admission associated with in-hospital mortality in several COVID Centers in Campania Region (Italy). METHODS: COVOCA is a multicentre retrospective observational cohort study, which involved 18 COVID Centers throughout Campania Region, Italy. Data were collected from patients who completed their hospitalization between March-June 2020. The endpoint was in-hospital mortality, assessed either from data at discharge or death certificate, whilst all exposure variables were collected at hospital admission. RESULTS: Among 618 COVID-19 hospitalized patients included in the study, 143 in-hospital mortality events were recorded, with a cumulative incidence of about 23%. At multivariable logistic analysis, male sex (OR 2.63, 95%CI 1.42–4.90; p = 0.001), Chronic Liver Disease (OR 5.88, 95%CI 2.39–14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21–5.68; p = 0.015) disclosed an independent association with a poor prognosis, Glasgow Coma Scale (GCS) and Respiratory Severity Scale allowed to identify at higher mortality risk. Sensitivity analysis further enhanced these findings. CONCLUSION: Mortality of patients hospitalized for COVID-19 appears strongly affected by both clinical conditions on admission and comorbidities. Originally, we observed a very poor outcome in subjects with a chronic liver disease, alongside with an increase of hepatic damage.

is ?:annotates of