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Quinolines and its derivatives are significant class of heterocyclic compounds which are identified as the key component in many natural products and biologically important molecules. We describe herein a facile method for the synthesis of quinoline derivatives from Morita‐Baylis‐Hillman (MBH) Alcohols via Palladium Catalyzed intramolecular aryl amination followed by allylic amination pathway. The reaction between a series of MBH alcohols and amino compounds (Tosyl, aliphatic and aromatic amines) under optimized reaction conditions with Pd(PPh(3))(2)Cl(2)/DPPP catalyst system, afforded the corresponding 1,2‐dihydroquinolines upto 95 % isolated yield.
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document_parses/pdf_json/eb512bf786bf0bbb96c7eff5eac17fec4db2951a.json; document_parses/pdf_json/c9a8230d373de15361763fa764a6cfb53a9984e8.json
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document_parses/pmc_json/PMC7753362.xml.json
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Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita‐Baylis‐Hillman Alcohols
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