PropertyValue
?:abstract
  • Many individuals possess B cells capable of recognizing epitopes on the spike glycoprotein of SARS-CoV-2. In this issue of the JCI, Paschold and Simnica et al. interrogated the frequency of SARS-CoV-2-specific B cell receptor rearrangements in healthy subjects based on age and cancer status. The authors found that, while SARS-CoV-2-specific antibody signatures can be identified in the repertoires of young, healthy individuals, such sequences are less frequent in elderly subjects or cancer patients. Overall, this study sheds light on B cell repertoire restrictions that might lead to an unfavorable clinical course of COVID-19 infection in risk populations.
is ?:annotates of
?:creator
?:doi
  • 10.1172/jci144685
?:doi
?:journal
  • The_Journal_of_clinical_investigation
?:license
  • unk
?:pmid
?:pmid
  • 33216735
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • SARS-CoV-2 B cell receptor signatures in risk populations.
?:type
?:year
  • 2020-11-20

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