PropertyValue
?:abstract
  • The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is one of seven human coronaviruses G-quadruplexes are intrinsic obstacles to genome replication Whether G-quadruplexes are present in human coronaviruses is unknown In the current study, we have predicted that all seven human coronaviruses harbor G-quadruplex sequences Conserved G-quadruplex sequences in SARS-CoV and SARS-CoV-2 were analyzed and verified by circular dichroism (CD) spectroscopy and Thioflavin T fluorescence assay Similar to SARS-CoV, SARS-CoV-2 encodes an nsP3 protein, which is predicted to associate with G-quadruplexes Targeting G-quadruplex sequences in the SARS-CoV-2 genome by G-quadruplex ligands could be a new way to conquer COVID-19
is ?:annotates of
?:creator
?:journal
  • Frontiers_in_Microbiology
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2
?:type
?:who_covidence_id
  • #918159
?:year
  • 2020

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