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?:abstract
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The sudden outburst of Coronavirus disease (COVID-19) has left the entire world to a standstill COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) As per the report from the WHO, more than 4 5 million people have been infected by SARS-CoV-2 with more than 3,00,000 deaths across the globe As of now, there is no therapeutic drug or vaccine approved for the treatment of SARS-CoV-2 infection Hence, the outbreak of COVID-19 poses a massive threat to humans Due to the time taking process of new drug design and development, drug repurposing might be the only viable solution to tackle COVID-19 RNAâ€dependent RNA polymerase (RdRp) catalyzes SARS-CoV-2 RNA replication, i e the synthesis of single-stranded RNA genomes, an absolutely necessary stefor the survival and growth of the virus Thus, RdRis an obvious target for antiviral drug design Interestingly, several plant-derived polyphenols have been shown to inhibit enzymatic activities of RdRof various RNA viruses including polio-virus type 1, parainfluenza virus type 3, and respiratory syncytial virus etc More importantly, natural polyphenols have been used as a dietary supplementation for humans for a long time and played a beneficial role in immune homeostasis Therefore, we were curious to study the binding of dietary polyphenols with RdRof SARS-CoV-2 and assess their potential as an effective therapy for COVID-19 In this present work, we made a library of twenty potent polyphenols that have shown substantial therapeutic effects against various diseases The polyphenols were successfully docked in the catalytic pocket of RdRof SARS-CoV and SARS-CoV-2, and detailed studies on ADME prediction, toxicity prediction and target analysis were performed The study reveals that EGCG, quercetagetin, and myricetin strongly bind to the active site of SARS-CoV-2 RdRp Our studies suggest that EGCG, quercetagetin, and myricetin can inhibit RdRand represent an effective therapy for COVID-19
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