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Once the treatment of refractory/relapsed multiple myeloma in the elderly is greatly influenced by the adherence of patients and family members, clinicians should be aware of patients\' behavior and lifestyle, as it may influence the individual treatment plan for each patient Furthermore, treatment with oral chemotherapy is of special value during the COVID-19 outbreak Multidisciplinary healthcare involvement is crucial in the management of polypharmacy, adverse events and dose adjustment due to comorbidities and natural loss of renal function with age Oral drugs simplify intake, reduce hospital visits, and improve autonomy and quality of life However, although oral drugs have advantages, they also transfer control and responsibility from the healthcare professional to the patient, who must be able to understand and follow the directions given Therefore, patient education and communication with healthcare professionals are critical for adherence
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