s0w5fio

Property	Value
?:abstract	Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus responsible for the coronavirus disease (COVID-19), characterized by acute respiratory distress syndrome and atypical pneumonia. In non-pregnant women, studies have shown that SARS-CoV-2 causes cardiac injury, which can result in myocardial inflammation and damage. Despite many studies investigating the extent of cardiac compromise in severely ill COVID-19 patients, little is known regarding its impact on pregnant women. Objective To illustrate the clinical, laboratory, radiological findings, and outcomes of COVID-19 pregnant patients who developed myocardial injury with ventricular dysfunction. Study Design We retrospectively reviewed the paper records of fifteen pregnant women with COVID-19, who developed myocardial injury on a single tertiary care hospital in the Dominican Republic. Patient\'s baseline characteristics, clinical picture, laboratory, and radiological findings were presented, and maternal and fetal outcomes were analyzed. Results Of 154 pregnant patients diagnosed with COVID-19 at our hospital during the study period, 15 (9.7%), developed myocardial injury. These patients\' mean age and gestational age were 29.87 ± 5.83 and 32.31 ± 3.68, respectively. 66.7% of patients presented with shortness of breath and 16.3% with palpitations. All patients were admitted to the intensive care unit, and 86.6% needed intubation. Patients developed myocardial injury confirmed with highly elevated troponin (34.6 [14.4-55.5 ng/ml]), and pro-BNP concentrations (209 [184-246 pg/ml]). Additionally, all patients developed left ventricular dysfunction demonstrated by an echocardiogram with a mean left ventricular ejection fraction (LVEF) of 37.67 ± 6.4 %. Two patients that presented with palpitations passed away a few days after admission. Conclusion Our study showed COVID-19 induced myocardial injury and left ventricular dysfunction in pregnant women with a 13.3% mortality rate which was attributed to malignant arrhythmias.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C0018805> <https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C0231218> <https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C0242973> <https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C0746730> <https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C1825598> <https://research.tib.eu/covid-19/entity/2s0w5fio_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Mercedes%2C_Brisandi_Ruiz%3B_Serwat%2C_Ayna%3B_Naffaa%2C_Lena%3B_Ramirez%2C_Nairovi%3B_Khalid%2C_Fatima%3B_Steward%2C_Sofia_B.%3B_Caro_Feliz%2C_Omar_Gabriel%3B_Kassab%2C_Mohamad%3B_Karout%2C_Lina>
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.ajog.2020.10.031>
?:doi	10.1016/j.ajog.2020.10.031
?:journal	Am_J_Obstet_Gynecol
?:license	els-covid
?:pdf_json_files	document_parses/pdf_json/77f27e9d82ba9eb934fe91993a700aa4c81a0098.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7577917>
?:pmid	<https://research.tib.eu/covid-19/entity/33098814.0>
?:pmid	33098814.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/2s0w5fio_HAS_C0018805_CAUSES_C0027059> <https://research.tib.eu/covid-19/entity/2s0w5fio_HAS_C0035222_COEXISTS_WITH_C0012634> <https://research.tib.eu/covid-19/entity/2s0w5fio_HAS_C1412002_COEXISTS_WITH_C0012634>
?:sha_id	<https://research.tib.eu/covid-19/entity/77f27e9d82ba9eb934fe91993a700aa4c81a0098>
?:source	Elsevier; Medline; PMC
?:title	New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-22

Property

Value

?:abstract

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus responsible for the coronavirus disease (COVID-19), characterized by acute respiratory distress syndrome and atypical pneumonia. In non-pregnant women, studies have shown that SARS-CoV-2 causes cardiac injury, which can result in myocardial inflammation and damage. Despite many studies investigating the extent of cardiac compromise in severely ill COVID-19 patients, little is known regarding its impact on pregnant women. Objective To illustrate the clinical, laboratory, radiological findings, and outcomes of COVID-19 pregnant patients who developed myocardial injury with ventricular dysfunction. Study Design We retrospectively reviewed the paper records of fifteen pregnant women with COVID-19, who developed myocardial injury on a single tertiary care hospital in the Dominican Republic. Patient\'s baseline characteristics, clinical picture, laboratory, and radiological findings were presented, and maternal and fetal outcomes were analyzed. Results Of 154 pregnant patients diagnosed with COVID-19 at our hospital during the study period, 15 (9.7%), developed myocardial injury. These patients\' mean age and gestational age were 29.87 ± 5.83 and 32.31 ± 3.68, respectively. 66.7% of patients presented with shortness of breath and 16.3% with palpitations. All patients were admitted to the intensive care unit, and 86.6% needed intubation. Patients developed myocardial injury confirmed with highly elevated troponin (34.6 [14.4-55.5 ng/ml]), and pro-BNP concentrations (209 [184-246 pg/ml]). Additionally, all patients developed left ventricular dysfunction demonstrated by an echocardiogram with a mean left ventricular ejection fraction (LVEF) of 37.67 ± 6.4 %. Two patients that presented with palpitations passed away a few days after admission. Conclusion Our study showed COVID-19 induced myocardial injury and left ventricular dysfunction in pregnant women with a 13.3% mortality rate which was attributed to malignant arrhythmias.

is ?:annotates of