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?:abstract
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Obesity represents a higher risk of severe COVID-19 infection, which may lead to the requirement of a mechanical ventilation in intensive care units and premature death The underlying mechanisms are multiple: alteration of the respiratory performance, presence of comorbidities such as diabetes, hypertension or obstructive sleep apnea, finally inadequate and excessive immunological responses, possibly aggravated by ectopic intrathoracic fat depots Thus, COVID-19 may challenge the so-called obesity paradox commonly reported by intensivists in patients with acute respiratory distress syndrome These findings require reinforced preventive and curative measures among obese patients to limit the risk of progression towards an unfavorable outcome in case of COVID-19 Lobesite represente un risque accru dinfection COVID-19 severe, amenant les patients en soins intensifs pour une assistance respiratoire avec risque de deces Les raisons en sont multiples : alteration de la mecanique ventilatoire, presence de comorbidites comme le diabete, lhypertension ou les apnees obstructives du sommeil, enfin, des reactions immunologique et inflammatoire inappropriees et excessives, possiblement encore accentuees par des depots de graisse ectopique intrathoraciques Ainsi, le COVID-19 pourrait remettre en cause le concept, appele obesity paradox , decrit par les medecins intensivistes chez les patients avec detresse respiratoire aigue Ces donnees imposent de renforcer les mesures preventives et curatives chez les patients obeses pour limiter le risque devolution defavorable en cas de COVID-19
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