ea6j90

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?:abstract	T-cells play key roles in immunity to COVID-19 as well as the development of severe disease T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19 In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19 T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed. Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19. In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients. Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/31ea6j90_hasAnnotation_C0017337> <https://research.tib.eu/covid-19/entity/31ea6j90_hasAnnotation_C1416467> <https://research.tib.eu/covid-19/entity/31ea6j90_hasAnnotation_C3540595>
?:creator	<https://research.tib.eu/covid-19/entity/Kalfaoglu%2C_B.%3B_Almeida-Santos%2C_J.%3B_Tye%2C_C._A.%3B_Satou%2C_Y.%3B_Ono%2C_M.> <https://research.tib.eu/covid-19/entity/Kalfaoglu%2C_Bahire%3B_Almeida-Santos%2C_Jos%C3%A9%3B_Tye%2C_Chanidapa_Adele%3B_Satou%2C_Yorifumi%3B_Ono%2C_Masahiro>
?:journal	Biochem._biophys._res._commun Biochemical_&_Biophysical_Research_Communications
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/31ea6j90_HAS_C1416467_STIMULATES_C0039194>
?:source	WHO
?:title	T-cell dysregulation in COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1064869 #940959
?:year	2020

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?:abstract

T-cells play key roles in immunity to COVID-19 as well as the development of severe disease T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19 In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19
T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed. Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19. In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients. Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19.

is ?:annotates of