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?:abstract
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Background: COVID-19 also known as SARS C0V-2, is now a pandemic which started in December 2019 in China RT-PCR based nucleic acid detection is currently the standard diagnostic method for COVID-19, but certain shortcomings make it unfeasible for use as a screening test Aims and objectives: To study the dynamics of IgM and IgG antibody, establish its role in diagnosis and prognosis of COVID-19 patients Methods: It was a cross-sectional study conducted over 100 RT PCR confirmed COVID-19 patients admitted in various wards of a dedicated Corona hospital, RNTMedical College, Udaipur, Rajasthan, India over a period of 2months – fromApril 2020 toMay 2020 Results: We performed an anti-SARS-CoV-2 IgG/IgM test on 100 confirmed COVID-19 patients and found that 61%patients hadantibody positivity Dynamics of antibody show that seroconversion, peaking, anddisappearance of IgMantibody occur at end of 1st week, 2nd week, and 3rdweek respectively, while for IgG seroconversion was seen at the end of 2nd week, and was persistently positive up to 32nd day of illness in our study Patients with development of anti-SARS-CoV-2 antibodies had a mild degree of illness with positive outcome and vice versa Conclusion: Our study concludes that serological responses have been observed in COVID-19 patients, and the dynamic pattern of these responses is consistent with acute viral infection which is useful to see the immune status of these patients and diagnosis of COVID-19
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