PropertyValue
?:abstract
  • A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.
?:creator
?:doi
  • 10.1093/infdis/jiaa224
?:doi
?:journal
  • J_Infect_Dis
?:license
  • cc-by-nc-nd
?:pdf_json_files
  • document_parses/pdf_json/1f02a45e5f0b5b6925c0b21ee8b4960544724b8c.json; document_parses/pdf_json/b88a62d76cf9e8eada60aefb3a86bffcbe85845d.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7197559.xml.json
?:pmcid
?:pmid
?:pmid
  • 32348495.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19
?:type
?:year
  • 2020-04-29

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/387spphe>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/387spphe>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all