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?:abstract
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The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74–100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
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?:doi
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?:doi
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10.1007/s00415-020-09996-w
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document_parses/pdf_json/bcd25643744df569cf4e8d5c65ec897a77e18fe3.json
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document_parses/pmc_json/PMC7305694.xml.json
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?:title
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First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease
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