PropertyValue
?:abstract
  • Spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2-SP, SARS-CoV-2-NP) are the main immunogenic targets for antibodies. We herein demonstrate that the glycosylation of SARS-CoV-2-NP masks some of its antibody epitopes. In many cases, this can lead to false-negative serological tests. Deglycosylation of SARS-CoV-2-NP significantly increased the number of positive tests. The glycosylation pattern analysis of this protein revealed that the putative N-linked glycosylation sites, at the amino acid positions 48 and 270, co-located with two of the main immunodominant B cell epitopes.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.bbrc.2020.11.060
?:doi
?:journal
  • Biochem_Biophys_Res_Commun
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/9cee86b075ccec62c051538188bddc2ec4e133f5.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7678427.xml.json
?:pmcid
?:pmid
?:pmid
  • 33276951.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Dual ELISA using SARS-CoV-2 nucleocapsid protein produced in E. coli and CHO cells reveals epitope masking by N-glycosylation
?:type
?:year
  • 2020-11-20

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