PropertyValue
?:abstract
  • [Image: see text] We report an alternative approach to the unnatural nucleobase fragment seen in remdesivir (Veklury). Remdesivir displays broad-spectrum antiviral activity and is currently being evaluated in Phase III clinical trials to treat patients with COVID-19. Our route relies on the formation of a cyanoamidine intermediate, which undergoes Lewis acid-mediated cyclization to yield the desired nucleobase. The approach is strategically distinct from prior routes and could further enable the synthesis of remdesivir and other small-molecule therapeutics.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1021/acs.orglett.0c03052
?:journal
  • Org_Lett
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/edb9695214723cc57fb55cf4adfabdb178783255.json; document_parses/pdf_json/b00f29547e698e5d0e1f7d2d115525c194851ec0.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7653677.xml.json
?:pmcid
?:pmid
?:pmid
  • 33085486.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase
?:type
?:year
  • 2020-10-21

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