PropertyValue
?:abstract
  • Type 2 leprosy reaction (T2LR), or Erythema Nodosum Leprosum (ENL), often poses a therapeutic challenge to clinicians and commonly requires long courses of steroids for control. While immunosuppressants are known to achieve control and lower steroid dependence in T2LR, the prospect of managing a severe T2LR in conjunction with COVID-19, with the concern of worsening COVID-19 with long-term immunosuppression has not previously been encountered. We report a case of severe T2LR treated with oral steroids and methotrexate, with COVID-19 infection acquired during hospital stay, and a favourable outcome achieved despite the continued use of immunosuppressants. We discuss the possible reasons for this both in terms of the drug pharmacodynamics and the immunological profile of T2LR.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1016/j.ijid.2020.12.024
?:journal
  • Int_J_Infect_Dis
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/8fae03c7f367b3f27bcfd15fde2a98c377b637b6.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7831392.xml.json
?:pmcid
?:pmid
?:pmid
  • 33326870.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Severe type 2 leprosy reaction with COVID-19 with a favourable outcome despite continued use of corticosteroids and methotrexate and a hypothesis on the possible immunological consequences
?:type
?:year
  • 2020-12-14

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