PropertyValue
?:abstract
  • The SARS-CoV-2 immune response in human milk has not yet been examined, though protecting infants and young children from COVID-19 is critical for limiting community transmission, and preventing serious illness and death. Here, milk samples from 8 COVID-19-recovered and 7 COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, while 80% exhibited significant IgA and secretory (s)Ab binding to the receptor binding domain (RBD). Additionally, 67% of samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality, and the potential for exploiting extracted milk sIgA for therapeutic use.
is ?:annotates of
?:creator
?:journal
  • iScience
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Robust and specific secretory IgA against SARS-CoV-2 detected in human milk
?:type
?:who_covidence_id
  • #893968
?:year
  • 2020

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/40btsc2y>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/40btsc2y>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all