PropertyValue
?:abstract
  • The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
?:creator
?:doi
  • 10.1080/22221751.2020.1732837
?:doi
?:journal
  • Emerg_Microbes_Infect
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/77b0c98d1a2ca46b219ad090074814c387c80d8f.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7054964.xml.json
?:pmcid
?:pmid
?:pmid
  • 32102625.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
?:type
?:year
  • 2020-02-26

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