uri1x

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?:abstract	INTRODUCTION: Covid-19 infection poses a serious challenge for immune-compromised patients with inflammatory autoimmune systemic diseases. We investigated the clinical-epidemiological findings of 1641 autoimmune systemic disease Italian patients during the Covid-19 pandemic. METHOD: This observational multicenter study included 1641 unselected patients with autoimmune systemic diseases from three Italian geographical areas with different prevalence of Covid-19 [high in north (Emilia Romagna), medium in central (Tuscany), and low in south (Calabria)] by means of telephone 6-week survey. Covid-19 was classified as (1) definite diagnosis of Covid-19 disease: presence of symptomatic Covid-19 infection, confirmed by positive oral/nasopharyngeal swabs; (2) highly suspected Covid-19 disease: presence of highly suggestive symptoms, in absence of a swab test. RESULTS: A significantly higher prevalence of patients with definite diagnosis of Covid-19 disease, or with highly suspected Covid-19 disease, or both the conditions together, was observed in the whole autoimmune systemic disease series, compared to “Italian general population” (p = .030, p = .001, p = .000, respectively); and for definite + highly suspected diagnosis of Covid-19 disease, in patients with autoimmune systemic diseases of the three regions (p = .000, for all comparisons with the respective regional general population). Moreover, significantly higher prevalence of definite + highly suspected diagnosis of Covid-19 disease was found either in patients with various “connective tissue diseases” compared to “inflammatory arthritis group” (p < .000), or in patients without ongoing conventional synthetic disease-modifying anti-rheumatic drugs treatments (p = .011). CONCLUSIONS: The finding of a higher prevalence of Covid-19 in patients with autoimmune systemic diseases is particularly important, suggesting the need to develop valuable prevention/management strategies, and stimulates in-depth investigations to verify the possible interactions between Covid-19 infection and impaired immune-system of autoimmune systemic diseases.
?:creator	<https://research.tib.eu/covid-19/entity/Ferri%2C_Clodoveo%3B_Giuggioli%2C_Dilia%3B_Raimondo%2C_Vincenzo%3B_L%E2%80%99Andolina%2C_Massimo%3B_Tavoni%2C_Antonio%3B_Cecchetti%2C_Riccardo%3B_Guiducci%2C_Serena%3B_Ursini%2C_Francesco%3B_Caminiti%2C_Maurizio%3B_Varcasia%2C_Giuseppe%3B_Gigliotti%2C_Pietro%3B_Pellegrini%2C_Roberta%3B_Olivo%2C_Domenico%3B_Colaci%2C_Michele%3B_Murdaca%2C_Giuseppe%3B_Brittelli%2C_Raffaele%3B_Mariano%2C_Giuseppa_Pagano%3B_Spinella%2C_Amelia%3B_Bellando-Randone%2C_Silvia%3B_Aiello%2C_Vincenzo%3B_Bilia%2C_Silvia%3B_Giannini%2C_Daiana%3B_Ferrari%2C_Tommaso%3B_Caminiti%2C_Rodolfo%3B_Brusi%2C_Veronica%3B_Meliconi%2C_Riccardo%3B_Fallahi%2C_Poupak%3B_Antonelli%2C_Alessandro>
?:doi	<https://research.tib.eu/covid-19/entity/10.1007/s10067-020-05334-7>
?:doi	10.1007/s10067-020-05334-7
?:journal	Clin_Rheumatol
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/39cef3ec8837de1c20185006cc7a98be39135335.json
?:pmc_json_files	document_parses/pmc_json/PMC7450255.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7450255>
?:pmid	<https://research.tib.eu/covid-19/entity/32852623.0>
?:pmid	32852623.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/39cef3ec8837de1c20185006cc7a98be39135335>
?:source	Medline; PMC
?:title	COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-08-27

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?:abstract

INTRODUCTION: Covid-19 infection poses a serious challenge for immune-compromised patients with inflammatory autoimmune systemic diseases. We investigated the clinical-epidemiological findings of 1641 autoimmune systemic disease Italian patients during the Covid-19 pandemic. METHOD: This observational multicenter study included 1641 unselected patients with autoimmune systemic diseases from three Italian geographical areas with different prevalence of Covid-19 [high in north (Emilia Romagna), medium in central (Tuscany), and low in south (Calabria)] by means of telephone 6-week survey. Covid-19 was classified as (1) definite diagnosis of Covid-19 disease: presence of symptomatic Covid-19 infection, confirmed by positive oral/nasopharyngeal swabs; (2) highly suspected Covid-19 disease: presence of highly suggestive symptoms, in absence of a swab test. RESULTS: A significantly higher prevalence of patients with definite diagnosis of Covid-19 disease, or with highly suspected Covid-19 disease, or both the conditions together, was observed in the whole autoimmune systemic disease series, compared to “Italian general population” (p = .030, p = .001, p = .000, respectively); and for definite + highly suspected diagnosis of Covid-19 disease, in patients with autoimmune systemic diseases of the three regions (p = .000, for all comparisons with the respective regional general population). Moreover, significantly higher prevalence of definite + highly suspected diagnosis of Covid-19 disease was found either in patients with various “connective tissue diseases” compared to “inflammatory arthritis group” (p < .000), or in patients without ongoing conventional synthetic disease-modifying anti-rheumatic drugs treatments (p = .011). CONCLUSIONS: The finding of a higher prevalence of Covid-19 in patients with autoimmune systemic diseases is particularly important, suggesting the need to develop valuable prevention/management strategies, and stimulates in-depth investigations to verify the possible interactions between Covid-19 infection and impaired immune-system of autoimmune systemic diseases.

?:creator