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Property	Value
?:abstract	Objective To determine the percentage of diagnosed and undiagnosed SARS-CoV-2 infection among a sample of US ED health care personnel (HCP) before July 2020. Methods Cross-sectional analysis of ED HCP in 20 geographically diverse university-affiliated EDs from May to July 2020, including case counts of prior laboratory-confirmed COVID-19 diagnoses among all ED HCP, then serology (with confirmatory testing) and reverse transcriptase-polymerase chain reaction (RT-PCR) testing in a sample of volunteers without a previous COVID-19 diagnosis. HCP were categorized as clinical (physicians, advanced practice providers, and nurses) and non-clinical staff (clerks, social workers, and case managers). Previously undiagnosed infection was based on positive SARS-CoV-2 serology or RT-PCR among HCP without prior diagnosis. Results Diagnosed COVID-19 occurred in 2.8% (193/6,788) HCP, and the prevalence was similar for nonclinical and clinical staff (3.8% vs. 2.7%; odds ratio, OR 1.5, 95% confidence interval, 95% CI 0.7-3.2). Among 1,606 HCP without previously diagnosed COVID-19, 29 (1.8%) had evidence of current or past SARS-CoV-2 infection. Most (62%, 18/29) who were seropositive did not think they had been infected, 76% (19/25) recalled COVID-19-compatible symptoms, and 89% (17/19) continued to work while symptomatic. Accounting for both diagnosed and undiagnosed infections, 4.6% (95% CI 2.8-7.5%) of ED HCP were estimated to have been infected with SARS-CoV-2, with 38% of those infections undiagnosed. Conclusions The estimated prevalence of SARS-CoV-2 infection was 4.6%, and over one-third of infections were undiagnosed. Undiagnosed SARS-CoV-2 infection may pose substantial risk for transmission to other staff and patients.
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?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.annemergmed.2020.12.007>
?:doi	10.1016/j.annemergmed.2020.12.007
?:journal	Ann_Emerg_Med
?:license	els-covid
?:pdf_json_files	document_parses/pdf_json/8f7f0b8003bdc0147cbbecf2bd9951e23c0de6a8.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7746085>
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/8f7f0b8003bdc0147cbbecf2bd9951e23c0de6a8>
?:source	Elsevier; PMC
?:title	Diagnosed and Undiagnosed COVID-19 in US Emergency Department Healthcare Personnel: A Cross-Sectional Analysis
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-17

Property

Value

?:abstract

Objective To determine the percentage of diagnosed and undiagnosed SARS-CoV-2 infection among a sample of US ED health care personnel (HCP) before July 2020. Methods Cross-sectional analysis of ED HCP in 20 geographically diverse university-affiliated EDs from May to July 2020, including case counts of prior laboratory-confirmed COVID-19 diagnoses among all ED HCP, then serology (with confirmatory testing) and reverse transcriptase-polymerase chain reaction (RT-PCR) testing in a sample of volunteers without a previous COVID-19 diagnosis. HCP were categorized as clinical (physicians, advanced practice providers, and nurses) and non-clinical staff (clerks, social workers, and case managers). Previously undiagnosed infection was based on positive SARS-CoV-2 serology or RT-PCR among HCP without prior diagnosis. Results Diagnosed COVID-19 occurred in 2.8% (193/6,788) HCP, and the prevalence was similar for nonclinical and clinical staff (3.8% vs. 2.7%; odds ratio, OR 1.5, 95% confidence interval, 95% CI 0.7-3.2). Among 1,606 HCP without previously diagnosed COVID-19, 29 (1.8%) had evidence of current or past SARS-CoV-2 infection. Most (62%, 18/29) who were seropositive did not think they had been infected, 76% (19/25) recalled COVID-19-compatible symptoms, and 89% (17/19) continued to work while symptomatic. Accounting for both diagnosed and undiagnosed infections, 4.6% (95% CI 2.8-7.5%) of ED HCP were estimated to have been infected with SARS-CoV-2, with 38% of those infections undiagnosed. Conclusions The estimated prevalence of SARS-CoV-2 infection was 4.6%, and over one-third of infections were undiagnosed. Undiagnosed SARS-CoV-2 infection may pose substantial risk for transmission to other staff and patients.

is ?:annotates of