vj01cpl | Knowledge4COVID-19

Property	Value
?:abstract	Pyrrolotriazine 1 is an important precursor to remdesivir. Initial results toward an efficient synthesis are disclosed consisting of sequential cyanation, amination, and triazine formation beginning from pyrrole. This route makes use of highly abundant, commoditized raw material inputs. The yield of triazine was doubled from 31% to 59%, and the synthetic step count was reduced from 4 to 2. These efforts help to secure the remdesivir supply chain.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/4vj01cpl_hasAnnotation_C0034325> <https://research.tib.eu/covid-19/entity/4vj01cpl_hasAnnotation_C0040877>
?:creator	<https://research.tib.eu/covid-19/entity/Paymode%2C_Dinesh_J%3B_Cardoso%2C_Flavio_S_P%3B_Agrawal%2C_Toolika%3B_Tomlin%2C_John_W%3B_Cook%2C_Daniel_W%3B_Burns%2C_Justina_M%3B_Stringham%2C_Rodger_W%3B_Sieber%2C_Joshua_D%3B_Gupton%2C_B_Frank%3B_Snead%2C_David_R>
?:journal	Org._lett
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	WHO
?:title	Expanding Access to Remdesivir via an Improved Pyrrolotriazine Synthesis: Supply Centered Synthesis
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#911526
?:year	2020

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