PropertyValue
?:abstract
  • Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with multiple applications in medicine. Here, we showed that ASA and SA present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects. In both in vivo and in vitro models, SA and ASA triggered endoplasmic reticulum (ER) stress, which culminates with the upregulation of the pro-apoptotic transcription factor C/EBP homologous protein (CHOP). These effects are initiated by ASA/SA-triggered Akt/mTOR/AMPK-dependent activation of nitric oxide synthase 3 (eNOS), which increases nitric oxide and reactive oxygen species production inducing ER stress response. In the end, we propose that ASA and SA instigate anticancer effects by a novel mechanism, the activation of ER stress.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1038/s41598-020-76824-6
?:journal
  • Sci_Rep
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/efd2a5dba343a823d79eb3bec3148b75f0b6f678.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7665072.xml.json
?:pmcid
?:pmid
?:pmid
  • 33184378.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis
?:type
?:year
  • 2020-11-12

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