PropertyValue
?:abstract
  • We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I) PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2 Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface Investigation of ENDOU\'s relevance to vertical transmission of SARS-CoV-2 is further warranted
  • We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU\'s relevance to vertical transmission of SARS-CoV-2 is further warranted.
is ?:annotates of
?:creator
?:journal
  • Placenta
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis - Potential roles of placental ACE2 and ENDOU
?:type
?:who_covidence_id
  • #1065531
  • #927821
?:year
  • 2020

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