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The continued success of the global vaccination effort relies upon both the use of safe vaccines and public confidence in their benefit and safety In recent years, there have been examples of dramatic falls in the gains made in vaccine coverage and disease prevention in both the developed world and in low and middle-income countries, where scares have resulted in loss of public confidence While vaccine hesitancy and antivaccine communication has become global, the ability to respond to such concerns has remained largely fractured without coordination between countries Isolated collaborations that have included multiple countries for active surveillance using pooled data have generated information on measles-containing vaccines and aseptic meningitis and idiopathic thrombocytopenic purpura, rotavirus vaccines and intussusception as well as pandemic influenza vaccine and Guillain-Barre syndrome and narcolepsy Sustainable infrastructure and capacity building are needed for both timely hypothesis testing and to assess new vaccines such as Ebola, dengue, malaria and typhoid introduced particularly into LMICs A proposal to utilize this infrastructure to evaluate the association with GBS with vaccination including an evaluation of potential genetic risk factors has been submitted for funding to NIH In addition, in February 2020, the network has begun discussions as to how the network can address the need for a global comparative study of COVID-19 vaccines when these vaccines become available In conclusion, capacity currently exists globally to assess vaccine safety across a network of geographically diverse sites Developing this capacity further will be critical to the assessment of COVID-19 vaccines and other newly introduced vaccines in the future
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Pediatric_Infectious_Disease_Journal
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Progress toward a global vaccine data network
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