PropertyValue
?:abstract
  • The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) in the cytoplasm (Raote et al., 2018). Here, we present a theoretical approach to investigate the physical mechanisms of TANGO1 ring assembly and how COPII polymerization, membrane tension, and force facilitate the formation of a transport intermediate for procollagen export. Our results indicate that a TANGO1 ring, by acting as a linactant, stabilizes the open neck of a nascent COPII bud. Elongation of such a bud into a transport intermediate commensurate with bulky procollagens is then facilitated by two complementary mechanisms: (i) by relieving membrane tension, possibly by TANGO1-mediated fusion of retrograde ERGIC membranes and (ii) by force application. Altogether, our theoretical approach identifies key biophysical events in TANGO1-driven procollagen export.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.7554/elife.59426
?:externalLink
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/c2ffed6383d4b64c9dea437d55fbdac8df30c9f3.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7704110.xml.json
?:pmcid
?:pmid
?:pmid
  • 33169667
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • A physical mechanism of TANGO1-mediated bulky cargo export
?:type
?:year
  • 2020-11-10

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