PropertyValue
?:abstract
  • We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.
?:creator
?:doi
  • 10.1159/000512503
?:doi
?:journal
  • Pathobiology
?:license
  • cc-by-nc
?:pdf_json_files
  • document_parses/pdf_json/1c62e3ac52f010843c73f2104133130fd800644f.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7705934.xml.json
?:pmcid
?:pmid
?:pmid
  • 33137805.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis
?:type
?:year
  • 2020-11-02

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