z974nea | Knowledge4COVID-19

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?:abstract	Data on the burden of Clostridioides difficile infection (CDI) in Coronavirus Disease 2019 (COVID-19) patients are scant. We conducted an observational, retrospective, multicenter, 1:3 case (COVID-19 patients with CDI)-control (COVID-19 patients without CDI) study in Italy to assess incidence and outcomes, and to identify risk factors for CDI in COVID-19 patients. From February through July 2020, 8402 COVID-19 patients were admitted to eight Italian hospitals; 38 CDI cases were identified, including 32 hospital-onset-CDI (HO-CDI) and 6 community-onset, healthcare-associated-CDI (CO-HCA-CDI). HO-CDI incidence was 4.4 × 10,000 patient-days. The percentage of cases recovering without complications at discharge (i.e., pressure ulcers, chronic heart decompensation) was lower than among controls (p = 0.01); in-hospital stays was longer among cases, 35.0 versus 19.4 days (p = 0.0007). The presence of a previous hospitalisation (p = 0.001), previous steroid administration (p = 0.008) and the administration of antibiotics during the stay (p = 0.004) were risk factors associated with CDI. In conclusions, CDI complicates COVID-19, mainly in patients with co-morbidities and previous healthcare exposures. Its association with antibiotic usage and hospital acquired bacterial infections should lead to strengthen antimicrobial stewardship programmes and infection prevention and control activities.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C0003232> <https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C0009566> <https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C0206669> <https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C0274281> <https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C1412491> <https://research.tib.eu/covid-19/entity/5z974nea_hasAnnotation_C1961112>
?:creator	<https://research.tib.eu/covid-19/entity/Granata%2C_Guido%3B_Bartoloni%2C_Alessandro%3B_Codeluppi%2C_Mauro%3B_Contadini%2C_Ilaria%3B_Cristini%2C_Francesco%3B_Fantoni%2C_Massimo%3B_Ferraresi%2C_Alice%3B_Fornabaio%2C_Chiara%3B_Grasselli%2C_Sara%3B_Lagi%2C_Filippo%3B_Masucci%2C_Luca%3B_Puoti%2C_Massimo%3B_Raimondi%2C_Alessandro%3B_Taddei%2C_Eleonora%3B_Trapani%2C_Filippo_Fabio%3B_Viale%2C_Pierluigi%3B_Johnson%2C_Stuart%3B_Petrosillo%2C_Nicola>
?:doi	<https://research.tib.eu/covid-19/entity/10.3390/jcm9123855>
?:doi	10.3390/jcm9123855
?:journal	J_Clin_Med
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/996198523792fd97eea176f8765671ee19b5000d.json
?:pmc_json_files	document_parses/pmc_json/PMC7761275.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7761275>
?:pmid	<https://research.tib.eu/covid-19/entity/33260943.0>
?:pmid	33260943.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/5z974nea_HAS_C0343386_COMPLICATES_C5203670>
?:sha_id	<https://research.tib.eu/covid-19/entity/996198523792fd97eea176f8765671ee19b5000d>
?:source	Medline; PMC
?:title	The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid)
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-27

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