PropertyValue
?:abstract
  • A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H(2)) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H(2) has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H(2) (1.3% H(2) + 21% O(2) + 77.7% N(2)) or control (21% O(2) + 79% N(2)) gas mixture for 1 h per day. H(2) significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H(2) was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H(2) on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H(2) exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H(2) improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H(2) exerts an anti-hypertensive effect in an animal model of hypertension.
is ?:annotates of
?:creator
?:doi
  • 10.1038/s41598-020-77349-8
?:doi
?:externalLink
?:journal
  • Sci_Rep
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/ef55780313d89b20c0d13c2bc5a35cead826e69c.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7692487.xml.json
?:pmcid
?:pmid
?:pmid
  • 33244027
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
?:type
?:year
  • 2020-11-26

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