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BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects patients younger than five years. In the absence of an available affordable diagnostic test, detailed clinical history and physical examination are still fundamental to make a diagnosis. METHODS: We present five representative cases with KD-like presentation; Systemic onset juvenile idiopathic arthritis, Mycoplasma-induced rash and mucositis, Staphylococcal scalded skin syndrome, BCGosis and the recently described Multisystemic inflammatory syndrome in children (MIS-C) associated with SARS-CoV2. RESULTS: Rash, fever and laboratory markers of inflammation can be present in several childhood diseases that may mimic KD. CONCLUSION: The term Kawasaki syndrome instead of Kawasaki disease may be more appropriate. Physicians should consider alternate diagnosis that may mimic KD, particularly consider MIS-C during the present pandemic since an aggressive diagnostic and therapeutic approach is needed.
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