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?:abstract
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The presentation of novel coronavirus disease 2019 (COVID-19) in children with kidney disease is largely unknown We report on 2 children with kidney disease not receiving long-term immunosuppression who were hospitalized due to COVID-19 The first case is an infant with end-stage kidney disease secondary to bilateral cystic dysplastic kidneys and posterior urethral valves receiving peritoneal dialysis, with a history of prematurity previously requiring mechanical ventilation in the neonatal intensive care unit, who presented with fever, hypertension, and emesis He had no respiratory symptoms and recovered with supportive care His hypertension was managed well with amlodipine The second case is a child with steroid-sensitive nephrotic syndrome who presented with a relapse of nephrotic syndrome with concurrent peritonitis and sepsis caused by Streptococcus agalactiae He was treated with antibiotics and prophylactic anticoagulation therspy Steroid therapy was initiated after 48 hours of antibiotic therapy Neither child required mechanical ventilation or developed COVID-19-related multisystem inflammatory syndrome
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The presentation of the novel coronavirus disease 2019 (COVID-19) in children with kidney disease is largely unknown. We report on two children with kidney disease not on chronic immunosuppression who were hospitalized due to COVID-19. The first case is an infant with end stage kidney disease (ESKD) secondary to bilateral cystic dysplastic kidneys and posterior urethral valves on peritoneal dialysis, with a history of prematurity previously requiring mechanical ventilation in the neonatal intensive care unit, who presented with fever, hypertension, and emesis. He had no respiratory symptoms and recovered with supportive care. His hypertension was managed well with amlodipine. The second case is a child with steroid sensitive nephrotic syndrome who presented with a relapse of nephrotic syndrome with concurrent peritonitis and streptococcal agalactiae sepsis. He was treated with antibiotics and prophylactic anticoagulation, and steroid therapy was initiated after 48 hours of antibiotics. Neither child required mechanical ventilation nor developed COVID-19 related multisystem inflammatory syndrome.
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