PropertyValue
?:abstract
  • Self-immolation (SI) is the key principle of ProTide nucleotide prodrugs such as remdesivir, which is currently used to treat COVID-19 patients Developing novel tailor-made SI systems requires new analytical methods for the detection and monitoring of SI We developed a robust method for SI analysis using novel phosphate-based SI linkers with NMR traceable cyclic intermediates to distinguish SI from alternative fragmentation pathways and to monitor cargo release in real time
  • Self-immolation (SI) is the key principle of ProTide nucleotide prodrugs such as remdesivir, which is currently used to treat COVID-19 patients. Developing novel tailor-made SI systems requires new analytical methods for the detection and monitoring of SI. We developed a robust method for SI analysis using novel phosphate-based SI linkers with NMR traceable cyclic intermediates to distinguish SI from alternative fragmentation pathways and to monitor cargo release in real time.
is ?:annotates of
?:creator
?:journal
  • Chem._commun._(Lond.,_1996,_Online)
  • Chemical_Communications
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Phosphate linkers with traceable cyclic intermediates for self-immolation detection and monitoring
?:type
?:who_covidence_id
  • #1065972
  • #968820
?:year
  • 2020
  • 2021

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